Anna Lottie Nueslein (Handlir) age 85, of New Market, MD passed away Friday, September 24, 2021. Born in Baltimore MD, to the late Frank J. and Lottie M.(Slaughter) Handlir. She was the loving wife to her late husband Henry Carl Nueslein, She is survived by her daughter Lisa Ann Nueslein of New Market, MD and son Brian H. Nueslein of Dayton, OH; granddaughters, Morgan and Madeline Nueslein; grandson Nicholas Nueslein and his wife Allison, all of Ohio; as well as brother and sister-in-law James and Louise Handlir; sister-in-law Vera (Nueslein) Freburger; and nieces Linda (Freburger) Henry , Michele Handlir and Donna (Handlir) Algarin and her husband Enrique Algarin; nephew James Freburger. She was preceded in death by her dear brother-in-law Charles Freburger, and sister-in-law Joan Nueslein. Anne was a graduate of The Catholic High School of Baltimore and retired after 30 years from the John's Hopkins University Applied Physics Laboratory. Ann, enjoyed golf, playing cards and games, acrylic painting, being an active parent with the Liberty Belle Drum and Baton Corp, and spending time with family, especially her grandchildren. Ann was blessed to enjoy 20 years of retirement in the Pinehurst, NC area. Ann was also passionate about her love and loyalty to the Catholic Church. The family will receive friends Wednesday, September 29, 2021 at Keeney and Basford P.A. Funeral Home, 106 E. Church St. Frederick MD, 21701 from 2:00 PM until 5:00 PM. A Mass of Christian Burial will be offered on Thursday September 30, 2021 at 11:00 AM, at St. St. Ignatius of Loyola Catholic Church, 4103 Prices Distillery Rd, Ijamsville, MD 21754. A Graveside Service will be held on Friday, October 1, 2021 at Most Holy Redeemer Cemetery 4430 Belair Rd, Baltimore, MD 21206